Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1015616

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as inhibition of colony formation after 5 to 8 days by colony assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship study of lamellarin derivatives.
Ishibashi F, Tanabe S, Oda T, Iwao M.
J Nat Prod (2002) 65 : 500 -504
PubMed 11975488 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.40 7.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL373114 LAMELLARIN D 1 7.98
CHEMBL517639 1 7.42
CHEMBL373113 1 7.40
CHEMBL105 MITOMYCIN 4.0 1 7.17
CHEMBL465260 1 7.16
CHEMBL194663 1 6.07
CHEMBL370322 1 5.96
CHEMBL365388 1 5.60
CHEMBL191994 1 5.40
CHEMBL517954 1 5.24
CHEMBL370730 1 4.96
CHEMBL465036 LAMELLARIN H 1 -
CHEMBL195359 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL373114 LAMELLARIN D IC50 = 10.5 nM 7.98
CHEMBL517639 IC50 = 38.0 nM 7.42
CHEMBL373113 IC50 = 39.5 nM 7.40
CHEMBL105 MITOMYCIN IC50 = 68.0 nM 7.17
CHEMBL465260 IC50 = 70.0 nM 7.16
CHEMBL194663 IC50 = 850.0 nM 6.07
CHEMBL370322 IC50 = 1100.0 nM 5.96
CHEMBL365388 IC50 = 2500.0 nM 5.60
CHEMBL191994 IC50 = 4000.0 nM 5.40
CHEMBL517954 IC50 = 5700.0 nM 5.24
CHEMBL370730 IC50 = 11000.0 nM 4.96
CHEMBL465036 LAMELLARIN H IC50 > 100000.0 nM -
CHEMBL195359 IC50 > 100000.0 nM -