Assay Detail
Functional
CHEMBL1015646
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Cytotoxicity against mouse L1210 cells after 24 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation, structure, synthesis, and antimitotic properties of combretastatins B-3 and B-4 from Combretum caffrum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.39 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36255 | COMBRETASTATIN A-1 | 1.0 | 1 | 6.22 |
| CHEMBL499970 | — | — | 1 | 6.00 |
| CHEMBL487612 | — | — | 1 | 6.00 |
| CHEMBL285152 | — | — | 1 | 5.70 |
| CHEMBL485822 | — | — | 1 | 5.52 |
| CHEMBL2093988 | — | — | 1 | 5.52 |
| CHEMBL488414 | — | — | 1 | 5.40 |
| CHEMBL307158 | — | — | 1 | 4.70 |
| CHEMBL519743 | — | — | 1 | 4.52 |
| CHEMBL313688 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36255 | COMBRETASTATIN A-1 | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL499970 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL487612 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL285152 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL485822 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2093988 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL488414 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL307158 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL519743 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL313688 | — | IC50 | = | 50000.0 | nM | 4.30 |