Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1015818

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat microsomal delta-(9)-desaturase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acyl-CoA desaturase 1 (CHEMBL5424)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Koltun DO, Vasilevich NI, Parkhill EQ, Glushkov AI, Zilbershtein TM, Mayboroda EI, Boze MA, Cole AG, Henderson I, Zautke NA, Brunn SA, Chu N, Hao J, Mollova N, Leung K, Chisholm JW, Zablocki J.
Bioorg Med Chem Lett (2009) 19 : 3050 -3053
PubMed 19394219 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.96 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL466674 1 6.72
CHEMBL467091 1 6.68
CHEMBL466313 1 6.60
CHEMBL466719 1 6.60
CHEMBL444433 1 6.58
CHEMBL512775 1 6.58
CHEMBL466720 1 6.57
CHEMBL512969 1 6.46
CHEMBL466314 1 6.06
CHEMBL466890 1 6.05
CHEMBL466257 1 5.93
CHEMBL466472 1 5.87
CHEMBL466889 1 5.59
CHEMBL467090 1 5.57
CHEMBL447081 1 5.51
CHEMBL467716 1 5.50
CHEMBL466672 1 5.47
CHEMBL466885 1 5.42
CHEMBL466444 1 5.41
CHEMBL466524 1 5.10
CHEMBL466087 1 4.94
CHEMBL466522 1 -
CHEMBL466891 1 -
CHEMBL466892 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL466674 IC50 = 190.0 nM 6.72
CHEMBL467091 IC50 = 208.0 nM 6.68
CHEMBL466313 IC50 = 251.0 nM 6.60
CHEMBL466719 IC50 = 250.0 nM 6.60
CHEMBL444433 IC50 = 261.0 nM 6.58
CHEMBL512775 IC50 = 260.0 nM 6.58
CHEMBL466720 IC50 = 268.0 nM 6.57
CHEMBL512969 IC50 = 348.0 nM 6.46
CHEMBL466314 IC50 = 865.0 nM 6.06
CHEMBL466890 IC50 = 890.0 nM 6.05
CHEMBL466257 IC50 = 1170.0 nM 5.93
CHEMBL466472 IC50 = 1360.0 nM 5.87
CHEMBL466889 IC50 = 2580.0 nM 5.59
CHEMBL467090 IC50 = 2690.0 nM 5.57
CHEMBL447081 IC50 = 3120.0 nM 5.51
CHEMBL467716 IC50 = 3200.0 nM 5.50
CHEMBL466672 IC50 = 3420.0 nM 5.47
CHEMBL466885 IC50 = 3850.0 nM 5.42
CHEMBL466444 IC50 = 3860.0 nM 5.41
CHEMBL466524 IC50 = 7970.0 nM 5.10
CHEMBL466087 IC50 = 11600.0 nM 4.94
CHEMBL466522 IC50 > 30000.0 nM -
CHEMBL466891 IC50 > 30000.0 nM -
CHEMBL466892 IC50 > 30000.0 nM -