Assay Detail

CHEMBL1015857

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of MAPK

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Application of combinatorial biocatalysis for a unique ring expansion of dihydroxymethylzearalenone.

Rich JO, Budde CL, McConeghey LD, Cotterill IC, Mozhaev VV, Singh SB, Goetz MA, Zhao A, Michels PC, Khmelnitsky YL.
Bioorg Med Chem Lett (2009) 19 : 3059 -3062
PubMed 19394221 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2012519	—	—	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2012519	—	IC50	=	4.0	nM	8.40