Assay Detail
Functional
CHEMBL1016090
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Inhibition of fetal calf serum-induced proliferation of human foreskin fibroblast assessed as [3H]thymidine incorporation after 4 days by scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.15 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56543 | — | — | 1 | 5.25 |
| CHEMBL473773 | — | — | 1 | 5.20 |
| CHEMBL463821 | — | — | 1 | 5.00 |
| CHEMBL405130 | WHI-P131 | 1.0 | 1 | - |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | - |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56543 | — | IC50 | = | 5584.0 | nM | 5.25 |
| CHEMBL473773 | — | IC50 | = | 6343.0 | nM | 5.20 |
| CHEMBL463821 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL405130 | WHI-P131 | IC50 | - | — | - | |
| CHEMBL221959 | TOFACITINIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL160 | CYCLOSPORINE | IC50 | > | 10000.0 | nM | - |