Assay Detail
Binding
CHEMBL1016136
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Inhibition of Plasmodium berghei ANKA DHODH
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium berghei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.26 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492720 | — | — | 1 | 6.58 |
| CHEMBL492529 | — | — | 1 | 6.42 |
| CHEMBL492520 | — | — | 1 | 5.89 |
| CHEMBL13380 | — | — | 1 | 5.82 |
| CHEMBL452392 | — | — | 1 | 5.62 |
| CHEMBL492719 | — | — | 1 | 5.50 |
| CHEMBL500504 | — | — | 1 | 5.43 |
| CHEMBL447995 | — | — | 1 | 5.40 |
| CHEMBL492530 | — | — | 1 | 5.40 |
| CHEMBL452465 | — | — | 1 | 5.24 |
| CHEMBL437480 | — | — | 1 | 5.14 |
| CHEMBL523163 | — | — | 1 | 5.00 |
| CHEMBL522325 | — | — | 1 | 4.96 |
| CHEMBL492528 | — | — | 1 | 4.80 |
| CHEMBL492695 | — | — | 1 | 4.68 |
| CHEMBL492712 | — | — | 1 | 4.68 |
| CHEMBL492336 | — | — | 1 | 4.60 |
| CHEMBL499296 | — | — | 1 | 4.51 |
| CHEMBL474842 | — | — | 1 | 4.26 |
| CHEMBL508404 | — | — | 1 | - |
| CHEMBL492497 | — | — | 1 | - |
| CHEMBL451525 | — | — | 1 | - |
| CHEMBL502389 | — | — | 1 | - |
| CHEMBL492711 | — | — | 1 | - |
| CHEMBL444928 | — | — | 1 | - |
| CHEMBL523691 | — | — | 1 | - |
| CHEMBL451417 | — | — | 1 | - |
| CHEMBL493761 | — | — | 1 | - |
| CHEMBL492550 | — | — | 1 | - |
| CHEMBL454269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492720 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL492529 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL492520 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL13380 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL452392 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL492719 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL500504 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL447995 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL492530 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL452465 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL437480 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL523163 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL522325 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL492528 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL492712 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL492695 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL492336 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL499296 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL474842 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL473816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475663 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL452667 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL514038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475664 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL474004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL523669 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL522991 | — | IC50 | - | — | - | |
| CHEMBL492549 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL506446 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL454269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL492550 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL493761 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL451417 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL523691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL444928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL492711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL502389 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL451525 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL492497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL508404 | — | IC50 | > | 100000.0 | nM | - |