Assay Detail
Functional
CHEMBL1016138
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Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 5.07 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492529 | — | — | 1 | 6.47 |
| CHEMBL492720 | — | — | 1 | 5.89 |
| CHEMBL13380 | — | — | 1 | 5.58 |
| CHEMBL492719 | — | — | 1 | 5.44 |
| CHEMBL492530 | — | — | 1 | 5.42 |
| CHEMBL492520 | — | — | 1 | 5.38 |
| CHEMBL447995 | — | — | 1 | 5.32 |
| CHEMBL492549 | — | — | 1 | 5.30 |
| CHEMBL492528 | — | — | 1 | 5.19 |
| CHEMBL437480 | — | — | 1 | 5.09 |
| CHEMBL492336 | — | — | 1 | 5.09 |
| CHEMBL499296 | — | — | 1 | 5.07 |
| CHEMBL492712 | — | — | 1 | 5.06 |
| CHEMBL522325 | — | — | 1 | 5.06 |
| CHEMBL452465 | — | — | 1 | 4.92 |
| CHEMBL523669 | — | — | 1 | 4.85 |
| CHEMBL474842 | — | — | 1 | 4.72 |
| CHEMBL452667 | — | — | 1 | 4.60 |
| CHEMBL454269 | — | — | 1 | 4.52 |
| CHEMBL514038 | — | — | 1 | 4.47 |
| CHEMBL502389 | — | — | 1 | 4.46 |
| CHEMBL475664 | — | — | 1 | 4.43 |
| CHEMBL474004 | — | — | 1 | 4.30 |
| CHEMBL452392 | — | — | 1 | - |
| CHEMBL444928 | — | — | 1 | - |
| CHEMBL492711 | — | — | 1 | - |
| CHEMBL492695 | — | — | 1 | - |
| CHEMBL451525 | — | — | 1 | - |
| CHEMBL523163 | — | — | 1 | - |
| CHEMBL492497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492529 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL492720 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL13380 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL492719 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL492530 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL492520 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL447995 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL492549 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL492528 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL437480 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL492336 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL499296 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL492712 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL522325 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL452465 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL523669 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL474842 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL452667 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL454269 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL514038 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL502389 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL475664 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL474004 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL473816 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL475663 | — | EC50 | - | — | - | |
| CHEMBL500504 | — | EC50 | - | — | - | |
| CHEMBL522991 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL506446 | — | EC50 | - | — | - | |
| CHEMBL492550 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL493761 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL451417 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL523691 | — | EC50 | - | — | - | |
| CHEMBL508404 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL492497 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL523163 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL451525 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL492695 | — | EC50 | - | — | - | |
| CHEMBL492711 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL444928 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL452392 | — | EC50 | > | 5000.0 | nM | - |