Assay Detail
Binding
CHEMBL1016154
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Inhibition of Plasmodium falciparum DHODH
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (CHEMBL3486) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.51 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492720 | — | — | 1 | 7.11 |
| CHEMBL492529 | — | — | 1 | 6.55 |
| CHEMBL447995 | — | — | 1 | 6.46 |
| CHEMBL13380 | — | — | 1 | 6.35 |
| CHEMBL492520 | — | — | 1 | 6.11 |
| CHEMBL452392 | — | — | 1 | 6.10 |
| CHEMBL492719 | — | — | 1 | 6.07 |
| CHEMBL492530 | — | — | 1 | 5.92 |
| CHEMBL499296 | — | — | 1 | 5.85 |
| CHEMBL437480 | — | — | 1 | 5.81 |
| CHEMBL452465 | — | — | 1 | 5.80 |
| CHEMBL492549 | — | — | 1 | 5.66 |
| CHEMBL492336 | — | — | 1 | 5.55 |
| CHEMBL492528 | — | — | 1 | 5.38 |
| CHEMBL500504 | — | — | 1 | 5.37 |
| CHEMBL492712 | — | — | 1 | 5.34 |
| CHEMBL523669 | — | — | 1 | 5.34 |
| CHEMBL522325 | — | — | 1 | 5.31 |
| CHEMBL475664 | — | — | 1 | 5.31 |
| CHEMBL522991 | — | — | 1 | 5.28 |
| CHEMBL523163 | — | — | 1 | 5.10 |
| CHEMBL514038 | — | — | 1 | 5.04 |
| CHEMBL492695 | — | — | 1 | 5.03 |
| CHEMBL474842 | — | — | 1 | 4.85 |
| CHEMBL451417 | — | — | 1 | 4.77 |
| CHEMBL474004 | — | — | 1 | 4.72 |
| CHEMBL502389 | — | — | 1 | 4.57 |
| CHEMBL493761 | — | — | 1 | 4.54 |
| CHEMBL506446 | — | — | 1 | 4.41 |
| CHEMBL444928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492720 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL492529 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL447995 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL13380 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL492520 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL452392 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL492719 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL492530 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL499296 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL437480 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL452465 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL492549 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL492336 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL492528 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL500504 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL492712 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL523669 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL522325 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL475664 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL522991 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL523163 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL514038 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL492695 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL474842 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL451417 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL474004 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL502389 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL493761 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL506446 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL473816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475663 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL452667 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL454269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL492550 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL523691 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL508404 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL492497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL492711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL451525 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL444928 | — | IC50 | > | 100000.0 | nM | - |