Assay Detail
Functional
CHEMBL1016194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.28 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491254 | — | — | 1 | 7.82 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.80 |
| CHEMBL447806 | — | — | 1 | 7.70 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.68 |
| CHEMBL307765 | — | — | 1 | 7.66 |
| CHEMBL490230 | — | — | 1 | 7.62 |
| CHEMBL489218 | — | — | 1 | 7.52 |
| CHEMBL430060 | APICIDIN | — | 1 | 7.48 |
| CHEMBL491253 | — | — | 1 | 7.46 |
| CHEMBL523640 | — | — | 1 | 7.33 |
| CHEMBL490228 | — | — | 1 | 7.30 |
| CHEMBL489010 | — | — | 1 | 7.28 |
| CHEMBL490032 | — | — | 1 | 7.24 |
| CHEMBL519035 | — | — | 1 | 7.23 |
| CHEMBL446605 | — | — | 1 | 7.17 |
| CHEMBL508866 | — | — | 1 | 7.00 |
| CHEMBL485506 | — | — | 1 | 6.85 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.68 |
| CHEMBL491452 | — | — | 1 | 6.54 |
| CHEMBL489011 | — | — | 1 | 6.30 |
| CHEMBL490229 | — | — | 1 | - |
| CHEMBL86537 | SPLITOMICIN | — | 1 | - |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491254 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL447806 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL307765 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL490230 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL489218 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL430060 | APICIDIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL491253 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL523640 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL490228 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL489010 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL490032 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL519035 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL446605 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL508866 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL485506 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL491452 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL489011 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL490229 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL86537 | SPLITOMICIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL27759 | ENTINOSTAT | IC50 | > | 10000.0 | nM | - |