Assay Detail
Functional
CHEMBL1016203
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Cytotoxicity against human MCF7 cells after 3 days by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.93 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477259 | — | — | 1 | 6.52 |
| CHEMBL451298 | — | — | 1 | 6.27 |
| CHEMBL477877 | — | — | 1 | 6.16 |
| CHEMBL514678 | — | — | 1 | 6.16 |
| CHEMBL515631 | — | — | 1 | 6.16 |
| CHEMBL490240 | — | — | 1 | 6.08 |
| CHEMBL478488 | — | — | 1 | 6.06 |
| CHEMBL477064 | — | — | 1 | 6.06 |
| CHEMBL477063 | — | — | 1 | 6.00 |
| CHEMBL452447 | — | — | 1 | 5.96 |
| CHEMBL504547 | — | — | 1 | 5.95 |
| CHEMBL477863 | — | — | 1 | 5.85 |
| CHEMBL489629 | — | — | 1 | 5.85 |
| CHEMBL477860 | — | — | 1 | 5.82 |
| CHEMBL477861 | — | — | 1 | 5.75 |
| CHEMBL521922 | — | — | 1 | 5.57 |
| CHEMBL489245 | — | — | 1 | 5.43 |
| CHEMBL478487 | — | — | 1 | 5.09 |
| CHEMBL477862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477259 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL451298 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL477877 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL514678 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL515631 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL490240 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL478488 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL477064 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL477063 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL452447 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL504547 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL477863 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL489629 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL477860 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL477861 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL521922 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL489245 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL478487 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL477862 | — | IC50 | > | 50000.0 | nM | - |