Assay Detail
Binding
CHEMBL1016224
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Inhibition of HIV1 RNase H
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.78 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502584 | — | — | 1 | 5.24 |
| CHEMBL16755 | — | — | 1 | 5.23 |
| CHEMBL456338 | — | — | 1 | 5.18 |
| CHEMBL444813 | — | — | 1 | 5.15 |
| CHEMBL456337 | — | — | 1 | 5.14 |
| CHEMBL456325 | — | — | 1 | 4.97 |
| CHEMBL526563 | — | — | 1 | 4.97 |
| CHEMBL509261 | — | — | 1 | 4.65 |
| CHEMBL446740 | — | — | 1 | 4.54 |
| CHEMBL456326 | — | — | 1 | 4.45 |
| CHEMBL455061 | — | — | 1 | 4.43 |
| CHEMBL461247 | — | — | 1 | 4.39 |
| CHEMBL443423 | — | — | 1 | 4.32 |
| CHEMBL461036 | — | — | 1 | 4.24 |
| CHEMBL446644 | — | — | 1 | - |
| CHEMBL444646 | — | — | 1 | - |
| CHEMBL512021 | — | — | 1 | - |
| CHEMBL456120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502584 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL16755 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL456338 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL444813 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL456337 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL456325 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL526563 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL509261 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL446740 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL456326 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL455061 | — | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL461247 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL443423 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL461036 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL446644 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL444646 | — | IC50 | > | 96000.0 | nM | - |
| CHEMBL512021 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL456120 | — | IC50 | > | 80000.0 | nM | - |