Assay Detail
Functional
CHEMBL1016314
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, cytotoxic and fluorescent properties of novel N-phosphorylalkyl substituted E,E-3,5-bis(arylidene)piperid-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.59 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348877 | — | — | 1 | 6.40 |
| CHEMBL358894 | — | — | 1 | 6.10 |
| CHEMBL486927 | — | — | 1 | 6.00 |
| CHEMBL488768 | — | — | 1 | 6.00 |
| CHEMBL521376 | — | — | 1 | 5.99 |
| CHEMBL484992 | — | — | 1 | 5.85 |
| CHEMBL530113 | — | — | 1 | 5.52 |
| CHEMBL487548 | — | — | 1 | 5.15 |
| CHEMBL488767 | — | — | 1 | 5.09 |
| CHEMBL521221 | — | — | 1 | 5.04 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348877 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL358894 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL486927 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL488768 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL521376 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL484992 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL530113 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL487548 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL488767 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL521221 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL852 | MELPHALAN | IC50 | = | 50000.0 | nM | 4.30 |