Assay Detail

CHEMBL1016583

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Functional

Agonist activity at adrenergic alpha2 receptor in rat vas deferens

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Vas deferens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.

Gentili F, Cardinaletti C, Vesprini C, Carrieri A, Ghelfi F, Farande A, Giannella M, Piergentili A, Quaglia W, Laurila JM, Huhtinen A, Scheinin M, Pigini M.
J Med Chem (2008) 51 : 4289 -4299
PubMed 18578476 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.52	8.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL128168	BIPHENYLINE	—	1	8.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL128168	BIPHENYLINE	EC50	=	3.02	nM	8.52