Assay Detail
Functional
CHEMBL1016859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay
42
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vibrio fischeri ES114 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LuxR (CHEMBL5867) ↗| Type | SINGLE PROTEIN |
| Organism | Vibrio fischeri (strain ATCC 700601 / ES114) |
Publication
Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.90 | 6.41 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450689 | — | — | 1 | 6.41 |
| CHEMBL513503 | — | — | 1 | 6.30 |
| CHEMBL457115 | — | — | 1 | 6.28 |
| CHEMBL468624 | — | — | 1 | 6.21 |
| CHEMBL467397 | — | — | 1 | 6.20 |
| CHEMBL468790 | — | — | 1 | 6.07 |
| CHEMBL463121 | — | — | 1 | 6.06 |
| CHEMBL502197 | — | — | 1 | 6.03 |
| CHEMBL468791 | — | — | 1 | 6.02 |
| CHEMBL457113 | — | — | 1 | 6.01 |
| CHEMBL511677 | — | — | 1 | 6.00 |
| CHEMBL503238 | — | — | 1 | 6.00 |
| CHEMBL458227 | — | — | 1 | 5.89 |
| CHEMBL508553 | — | — | 1 | 5.89 |
| CHEMBL264944 | — | — | 1 | 5.87 |
| CHEMBL459084 | — | — | 1 | 5.85 |
| CHEMBL458226 | — | — | 1 | 5.82 |
| CHEMBL442902 | — | — | 1 | 5.77 |
| CHEMBL502443 | — | — | 1 | 5.72 |
| CHEMBL457057 | — | — | 2 | 5.70 |
| CHEMBL456052 | — | — | 1 | 5.68 |
| CHEMBL506438 | — | — | 1 | 5.68 |
| CHEMBL467396 | — | — | 1 | 5.66 |
| CHEMBL456719 | — | — | 1 | 5.66 |
| CHEMBL458672 | — | — | 1 | 5.62 |
| CHEMBL459083 | — | — | 2 | 5.60 |
| CHEMBL444924 | — | — | 1 | 5.57 |
| CHEMBL512914 | — | — | 1 | 5.52 |
| CHEMBL499747 | — | — | 1 | - |
| CHEMBL498921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450689 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL513503 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL457115 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL468624 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL467397 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL468790 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL463121 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL502197 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL468791 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL457113 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL511677 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL503238 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL458227 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL508553 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL264944 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL459084 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL458226 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL442902 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL502443 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL457057 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL456052 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL506438 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL467396 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL456719 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL458672 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL459083 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL444924 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL512914 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL258912 | — | IC50 | - | — | - | |
| CHEMBL405298 | — | IC50 | - | — | - | |
| CHEMBL503197 | — | IC50 | - | — | - | |
| CHEMBL457057 | — | Inhibition | = | 91.0 | % | - |
| CHEMBL459083 | — | Inhibition | = | 85.0 | % | - |
| CHEMBL509975 | — | IC50 | - | — | - | |
| CHEMBL456058 | — | IC50 | - | — | - | |
| CHEMBL456059 | — | IC50 | - | — | - | |
| CHEMBL498921 | — | IC50 | - | — | - | |
| CHEMBL458671 | — | IC50 | - | — | - | |
| CHEMBL501141 | — | IC50 | - | — | - | |
| CHEMBL456928 | — | IC50 | - | — | - | |
| CHEMBL508554 | — | IC50 | - | — | - | |
| CHEMBL499747 | — | IC50 | - | — | - |