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Assay Detail

CHEMBL1016906

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 24 hrs by [3H]hypoxanthine uptake
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway.
Acharya BN, Saraswat D, Kaushik MP.
Eur J Med Chem (2008) 43 : 2840 -2852
PubMed 18395298 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.63 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37647 1 7.52
CHEMBL37404 1 7.47
CHEMBL34804 1 7.40
CHEMBL37492 1 7.30
CHEMBL35439 1 6.82
CHEMBL36404 1 6.60
CHEMBL34930 2 6.46
CHEMBL320310 1 6.46
CHEMBL36532 1 6.21
CHEMBL9395 1 6.00
CHEMBL512200 1 5.96
CHEMBL457111 1 5.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37647 IC50 = 30.0 nM 7.52
CHEMBL37404 IC50 = 34.0 nM 7.47
CHEMBL34804 IC50 = 40.0 nM 7.40
CHEMBL37492 IC50 = 50.0 nM 7.30
CHEMBL35439 IC50 = 150.0 nM 6.82
CHEMBL36404 IC50 = 250.0 nM 6.60
CHEMBL34930 IC50 = 350.0 nM 6.46
CHEMBL320310 IC50 = 350.0 nM 6.46
CHEMBL36532 IC50 = 620.0 nM 6.21
CHEMBL34930 IC50 = 800.0 nM 6.10
CHEMBL9395 IC50 = 1000.0 nM 6.00
CHEMBL512200 IC50 = 1100.0 nM 5.96
CHEMBL457111 IC50 = 1200.0 nM 5.92