Assay Detail
Functional
CHEMBL1017174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, cytotoxic and fluorescent properties of novel N-phosphorylalkyl substituted E,E-3,5-bis(arylidene)piperid-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.42 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487548 | — | — | 1 | 6.15 |
| CHEMBL530113 | — | — | 1 | 5.92 |
| CHEMBL486927 | — | — | 1 | 5.88 |
| CHEMBL488768 | — | — | 1 | 5.85 |
| CHEMBL348877 | — | — | 1 | 5.81 |
| CHEMBL521221 | — | — | 1 | 5.74 |
| CHEMBL488767 | — | — | 1 | 5.52 |
| CHEMBL521376 | — | — | 1 | 5.40 |
| CHEMBL358894 | — | — | 1 | 5.22 |
| CHEMBL484992 | — | — | 1 | 4.82 |
| CHEMBL488567 | — | — | 1 | 4.52 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487548 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL530113 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL486927 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL488768 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL348877 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL521221 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL488767 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL521376 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL358894 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL484992 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL488567 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL852 | MELPHALAN | IC50 | = | 70000.0 | nM | 4.16 |