Assay Detail
Functional
CHEMBL1017260
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Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 7G8 in human erythrocytes by DAPI stain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.38 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462360 | — | — | 1 | 8.10 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.34 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.32 |
| CHEMBL461155 | — | — | 1 | 7.08 |
| CHEMBL461156 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462360 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL461155 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL461156 | — | EC50 | = | 91.0 | nM | 7.04 |