Assay Detail
Binding
CHEMBL1017447
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LFA1 expressed in human JY cells interaction with ICAM1-IG expressed in human HeLa cell monolayer after 45 mins by cell adhesion assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | JY |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cucurbitacins, cell adhesion inhibitors from Conobea scoparioides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.29 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455056 | CUCURBITACIN E | — | 1 | 6.75 |
| CHEMBL507237 | CUCURBITACIN B | — | 1 | 6.52 |
| CHEMBL387737 | CUCURBITACIN I | — | 1 | 6.02 |
| CHEMBL493646 | CUCURBITACIN D | — | 1 | 5.87 |
| CHEMBL564629 | CUCURBITACIN R | — | 1 | - |
| CHEMBL480111 | CUCURBITACIN L | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455056 | CUCURBITACIN E | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL507237 | CUCURBITACIN B | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL387737 | CUCURBITACIN I | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL493646 | CUCURBITACIN D | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL564629 | CUCURBITACIN R | IC50 | > | 50000.0 | nM | - |
| CHEMBL480111 | CUCURBITACIN L | IC50 | > | 50000.0 | nM | - |