Assay Detail
Binding
CHEMBL1017607
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Inhibition of voltage-gated sodium channel in Wistar rat forebrain synaptosomes assessed as inhibition of [14C]guanidium ion flux
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 4.99 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466273 | — | — | 1 | 6.40 |
| CHEMBL466104 | — | — | 1 | 6.05 |
| CHEMBL467283 | — | — | 1 | 6.00 |
| CHEMBL513130 | — | — | 1 | 6.00 |
| CHEMBL466097 | — | — | 1 | 6.00 |
| CHEMBL467111 | — | — | 1 | 6.00 |
| CHEMBL511409 | — | — | 1 | 5.70 |
| CHEMBL511602 | — | — | 1 | 5.70 |
| CHEMBL448556 | — | — | 1 | 5.58 |
| CHEMBL468109 | — | — | 1 | 5.52 |
| CHEMBL466476 | — | — | 1 | 5.52 |
| CHEMBL466692 | — | — | 1 | 5.40 |
| CHEMBL512600 | — | — | 1 | 5.40 |
| CHEMBL466682 | — | — | 1 | 5.40 |
| CHEMBL467908 | — | — | 1 | 5.40 |
| CHEMBL467320 | — | — | 1 | 5.30 |
| CHEMBL511217 | — | — | 1 | 5.30 |
| CHEMBL467936 | — | — | 1 | 5.30 |
| CHEMBL511926 | — | — | 1 | 5.30 |
| CHEMBL467322 | — | — | 1 | 5.22 |
| CHEMBL466105 | — | — | 1 | 5.10 |
| CHEMBL466676 | — | — | 1 | 4.92 |
| CHEMBL510336 | — | — | 1 | 4.85 |
| CHEMBL467920 | — | — | 1 | 4.85 |
| CHEMBL511893 | — | — | 1 | 4.82 |
| CHEMBL448430 | — | — | 1 | 4.82 |
| CHEMBL467110 | — | — | 1 | 4.80 |
| CHEMBL466718 | — | — | 1 | 4.77 |
| CHEMBL512079 | — | — | 1 | 4.76 |
| CHEMBL467937 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466273 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL466104 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL513130 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL466097 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL467111 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL467283 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL511409 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL511602 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL448556 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL468109 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL466476 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL466682 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL467908 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL512600 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL466692 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL467320 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL511926 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL467936 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL511217 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL467322 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL466105 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL466676 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL510336 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL467920 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL448430 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL511893 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL467110 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL466718 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL512079 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL467937 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL511401 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL467129 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL513499 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL28854 | SIPATRIGINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL512619 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL466278 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL466918 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL467708 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL512620 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL513134 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL466917 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL466926 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL467520 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL466927 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL467707 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL467519 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL467291 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL466715 | — | IC50 | = | 44200.0 | nM | 4.36 |
| CHEMBL511382 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL466507 | — | IC50 | = | 63000.0 | nM | 4.20 |