Assay Detail
Binding
CHEMBL1017614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]BW202W92 from voltage-gated sodium channel in Wistar rat forebrain synaptosomes by liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.99 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448556 | — | — | 1 | 7.40 |
| CHEMBL28854 | SIPATRIGINE | 2.0 | 1 | 6.30 |
| CHEMBL741 | LAMOTRIGINE | 4.0 | 1 | 5.58 |
| CHEMBL512079 | — | — | 1 | 5.48 |
| CHEMBL466715 | — | — | 1 | 5.17 |
| CHEMBL512619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448556 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL28854 | SIPATRIGINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL741 | LAMOTRIGINE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL512079 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL466715 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL512619 | — | IC50 | = | 110000.0 | nM | - |