Assay Detail
Binding
CHEMBL1018069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Partial synthesis and antitubulin activity of minor colchicum alkaloids: N-acetoacetyl-deacetylcolchicine and 2-demethylspeciosine (speciocolchine).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.24 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.62 |
| CHEMBL498053 | — | — | 1 | 5.62 |
| CHEMBL312862 | DEMECOLCINE | 2.0 | 1 | 5.62 |
| CHEMBL1063 | DEACETYLCOLCHICINE | — | 1 | 5.52 |
| CHEMBL314457 | SPECIOSINE | — | 1 | 5.50 |
| CHEMBL1080 | 2-DESMETHYLCOLCHICIN | — | 1 | 5.43 |
| CHEMBL505987 | — | — | 1 | 4.92 |
| CHEMBL497060 | — | — | 1 | 4.72 |
| CHEMBL496873 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL498053 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL312862 | DEMECOLCINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1063 | DEACETYLCOLCHICINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL314457 | SPECIOSINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1080 | 2-DESMETHYLCOLCHICIN | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL505987 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL497060 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL496873 | — | IC50 | = | 67000.0 | nM | 4.17 |