Assay Detail
Functional
CHEMBL1018362
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Inhibition of cholesterol synthesis in rat hepatocytes
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 9.04 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455524 | — | — | 1 | 9.92 |
| CHEMBL488297 | — | — | 1 | 9.82 |
| CHEMBL487632 | — | — | 1 | 9.77 |
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 9.64 |
| CHEMBL504314 | — | — | 1 | 9.57 |
| CHEMBL471745 | — | — | 1 | 9.54 |
| CHEMBL488636 | — | — | 1 | 9.52 |
| CHEMBL488821 | — | — | 1 | 9.51 |
| CHEMBL488298 | — | — | 1 | 9.42 |
| CHEMBL503128 | — | — | 1 | 9.33 |
| CHEMBL481660 | — | — | 1 | 9.17 |
| CHEMBL452139 | — | — | 1 | 9.10 |
| CHEMBL520068 | — | — | 1 | 9.00 |
| CHEMBL527431 | — | — | 1 | 8.99 |
| CHEMBL487631 | — | — | 1 | 8.99 |
| CHEMBL488471 | — | — | 1 | 8.94 |
| CHEMBL471744 | — | — | 1 | 8.87 |
| CHEMBL504300 | — | — | 1 | 8.86 |
| CHEMBL465885 | — | — | 1 | 8.74 |
| CHEMBL487278 | — | — | 1 | 8.63 |
| CHEMBL488300 | — | — | 1 | 8.55 |
| CHEMBL501917 | — | — | 1 | 8.44 |
| CHEMBL521039 | — | — | 1 | 8.23 |
| CHEMBL444210 | — | — | 1 | 7.86 |
| CHEMBL488299 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455524 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL488297 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL487632 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL504314 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL471745 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL488636 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL488821 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL488298 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL503128 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL481660 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL452139 | — | IC50 | = | 0.802 | nM | 9.10 |
| CHEMBL520068 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL527431 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL487631 | — | IC50 | = | 1.03 | nM | 8.99 |
| CHEMBL488471 | — | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL471744 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL504300 | — | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL465885 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL487278 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL488300 | — | IC50 | = | 2.81 | nM | 8.55 |
| CHEMBL501917 | — | IC50 | = | 3.63 | nM | 8.44 |
| CHEMBL521039 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL444210 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL488299 | — | IC50 | = | 26.4 | nM | 7.58 |