Assay Detail
Binding
CHEMBL1018747
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Selectivity ratio of Ki for dopamine D1 receptor to Ki for dopamine D2 receptor in rat forebrain
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.94 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270426 | — | — | 1 | 9.70 |
| CHEMBL468677 | — | — | 1 | 8.52 |
| CHEMBL482276 | — | — | 1 | 8.10 |
| CHEMBL27559 | — | — | 1 | 7.62 |
| CHEMBL405345 | — | — | 1 | 7.42 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.27 |
| CHEMBL468056 | — | — | 1 | - |
| CHEMBL255229 | — | — | 1 | - |
| CHEMBL513174 | — | — | 1 | - |
| CHEMBL403550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270426 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL468677 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL482276 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL27559 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL405345 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL53 | APOMORPHINE | Ki | = | 532.0 | nM | 6.27 |
| CHEMBL468056 | — | Ki | > | 112.0 | nM | - |
| CHEMBL255229 | — | Ki | > | 138.0 | nM | - |
| CHEMBL513174 | — | Ki | > | 529.0 | nM | - |
| CHEMBL403550 | — | Ki | > | 58.0 | nM | - |