Assay Detail
Functional
CHEMBL1018750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.99 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 7.42 |
| CHEMBL508369 | — | — | 1 | 6.80 |
| CHEMBL509312 | — | — | 1 | 6.70 |
| CHEMBL445737 | — | — | 1 | 6.30 |
| CHEMBL443438 | — | — | 1 | 5.68 |
| CHEMBL459029 | — | — | 1 | 5.48 |
| CHEMBL453685 | — | — | 1 | 5.21 |
| CHEMBL503752 | — | — | 1 | 5.21 |
| CHEMBL448571 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31400 | ELINAFIDE | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL508369 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL509312 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL445737 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL443438 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL459029 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL453685 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL503752 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL448571 | — | IC50 | = | 7300.0 | nM | 5.14 |