Assay Detail
Functional
CHEMBL1018835
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Inhibition of LPS-induced IL6 production in human PBMC after 24 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.29 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494338 | — | — | 1 | 8.49 |
| CHEMBL492749 | — | — | 1 | 8.46 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494338 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL492749 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 12.0 | nM | 7.92 |