Assay Detail
Binding
CHEMBL1018986
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Inhibition of human MMP13
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.71 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514794 | — | — | 1 | 8.10 |
| CHEMBL511942 | — | — | 1 | 7.14 |
| CHEMBL468901 | — | — | 1 | 6.40 |
| CHEMBL468900 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514794 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL511942 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL468901 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL468900 | — | IC50 | = | 6600.0 | nM | 5.18 |