Assay Detail
Binding
CHEMBL1019002
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Inhibition of mushroom tyrosine kinase assessed as oxidation of 0.25 mM L-3,4-dihydroxyphenylalanine
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitory activity on mushroom tyrosinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443605 | HEXYLRESORCINOL | -1.0 | 1 | 6.01 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 5.02 |
| CHEMBL24147 | RESORCINOL | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443605 | HEXYLRESORCINOL | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL24147 | RESORCINOL | IC50 | = | 1440000.0 | nM | - |