Assay Detail
Functional
CHEMBL1019006
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Anticorpulence activity against mouse 3T3L1 cells assessed as inhibition of lipid droplet accumulation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 3T3-L1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.33 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77993 | 3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE | — | 1 | 4.55 |
| CHEMBL451707 | — | — | 1 | 4.37 |
| CHEMBL307341 | AURAPTENE | — | 1 | 4.33 |
| CHEMBL73930 | TANGERETIN | — | 1 | 4.32 |
| CHEMBL76447 | NOBILETIN | — | 1 | 4.30 |
| CHEMBL513494 | DIHYDROXYBERGAMOTTIN | — | 1 | 4.28 |
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | — | 1 | 4.24 |
| CHEMBL226507 | SINENSETIN | — | 1 | 4.23 |
| CHEMBL242711 | BERGAPTOL | — | 1 | - |
| CHEMBL1192 | XANTHOTOXOL | — | 1 | - |
| CHEMBL449317 | HESPERIDIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77993 | 3,5,6,7,8,3',4'-HEPTAMETHOXYFLAVONE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL451707 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL307341 | AURAPTENE | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL73930 | TANGERETIN | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL76447 | NOBILETIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL513494 | DIHYDROXYBERGAMOTTIN | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL226507 | SINENSETIN | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL242711 | BERGAPTOL | IC50 | > | 500000.0 | nM | - |
| CHEMBL1192 | XANTHOTOXOL | IC50 | > | 500000.0 | nM | - |
| CHEMBL449317 | HESPERIDIN | IC50 | = | 311000.0 | nM | - |