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Assay Detail

CHEMBL1019291

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ADMET
Cytotoxicity against human H9 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type H9
Confidence 1 — Organism
Curated By Autocuration

Target

H9 (CHEMBL614806)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.
Tatematsu H, Kilkuskie RE, Corrigan AJ, Bodner AJ, Lee KH.
J Nat Prod (1991) 54 : 632 -637
PubMed 1919593 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 6.65 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL18981 THIOCOLCHICINE 1 8.74
CHEMBL292669 1 8.26
CHEMBL83406 1 8.06
CHEMBL107 COLCHICINE 4.0 1 8.00
CHEMBL298240 1 7.89
CHEMBL287634 1 7.70
CHEMBL277239 1 7.33
CHEMBL357199 1 7.07
CHEMBL282519 1 6.75
CHEMBL1063 DEACETYLCOLCHICINE 1 6.70
CHEMBL1080 2-DESMETHYLCOLCHICIN 1 6.58
CHEMBL464647 1 6.57
CHEMBL465445 1 6.54
CHEMBL463455 1 6.24
CHEMBL89087 1 6.18
CHEMBL465237 1 6.03
CHEMBL516667 1 5.96
CHEMBL465327 1 5.92
CHEMBL517186 1 5.89
CHEMBL451900 1 5.85
CHEMBL465446 1 5.55
CHEMBL9892 1 4.64
CHEMBL509483 1 4.52
CHEMBL522985 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL18981 THIOCOLCHICINE EC50 = 1.8 nM 8.74
CHEMBL292669 EC50 = 5.5 nM 8.26
CHEMBL83406 EC50 = 8.8 nM 8.06
CHEMBL107 COLCHICINE EC50 = 10.0 nM 8.00
CHEMBL298240 EC50 = 13.0 nM 7.89
CHEMBL287634 EC50 = 20.0 nM 7.70
CHEMBL277239 EC50 = 47.0 nM 7.33
CHEMBL357199 EC50 = 85.0 nM 7.07
CHEMBL282519 EC50 = 180.0 nM 6.75
CHEMBL1063 DEACETYLCOLCHICINE EC50 = 200.0 nM 6.70
CHEMBL1080 2-DESMETHYLCOLCHICIN EC50 = 260.0 nM 6.58
CHEMBL464647 EC50 = 270.0 nM 6.57
CHEMBL465445 EC50 = 290.0 nM 6.54
CHEMBL463455 EC50 = 570.0 nM 6.24
CHEMBL89087 EC50 = 660.0 nM 6.18
CHEMBL465237 EC50 = 940.0 nM 6.03
CHEMBL516667 EC50 = 1100.0 nM 5.96
CHEMBL465327 EC50 = 1200.0 nM 5.92
CHEMBL517186 EC50 = 1300.0 nM 5.89
CHEMBL451900 EC50 = 1400.0 nM 5.85
CHEMBL465446 EC50 = 2800.0 nM 5.55
CHEMBL9892 EC50 = 23000.0 nM 4.64
CHEMBL509483 EC50 = 30000.0 nM 4.52
CHEMBL522985 EC50 > 2700.0 nM -