Assay Detail
Functional
CHEMBL1019309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiamnesic activity against Entamoeba histolytica HM-1:IMSS after 72 hrs by trypan blue exclusion method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new 2-(5-substituted-3-phenyl-2-pyrazolinyl)-1,3-thiazolino[5,4-b]quinoxaline derivatives and evaluation of their antiamoebic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.85 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491969 | — | — | 1 | 6.77 |
| CHEMBL491300 | — | — | 1 | 6.64 |
| CHEMBL489744 | — | — | 1 | 6.52 |
| CHEMBL491720 | — | — | 1 | 6.05 |
| CHEMBL510606 | — | — | 1 | 5.96 |
| CHEMBL491931 | — | — | 1 | 5.89 |
| CHEMBL504473 | — | — | 1 | 5.85 |
| CHEMBL522479 | — | — | 1 | 5.83 |
| CHEMBL523638 | — | — | 1 | 5.83 |
| CHEMBL489743 | — | — | 1 | 5.80 |
| CHEMBL508817 | — | — | 1 | 5.79 |
| CHEMBL491128 | — | — | 1 | 5.79 |
| CHEMBL7976 | CHALCONE | — | 1 | 5.77 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.75 |
| CHEMBL488094 | — | — | 1 | 5.75 |
| CHEMBL492092 | — | — | 1 | 5.75 |
| CHEMBL492091 | — | — | 1 | 5.75 |
| CHEMBL491925 | — | — | 1 | 5.72 |
| CHEMBL442671 | — | — | 1 | 5.70 |
| CHEMBL375905 | — | — | 1 | 5.67 |
| CHEMBL503204 | — | — | 1 | 5.65 |
| CHEMBL474682 | — | — | 1 | 5.58 |
| CHEMBL490105 | — | — | 1 | 5.50 |
| CHEMBL454264 | — | — | 1 | 5.46 |
| CHEMBL521584 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491969 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL491300 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL489744 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL491720 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL510606 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL491931 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL504473 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL522479 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL523638 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL489743 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL508817 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL491128 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL7976 | CHALCONE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL488094 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL492092 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL492091 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL491925 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL442671 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL375905 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL503204 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL474682 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL490105 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL454264 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL521584 | — | IC50 | = | 4370.0 | nM | 5.36 |