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Assay Detail

CHEMBL1019440

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Binding
Inhibition of 15-lipoxygenase form soybean
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design and synthesis of 4-methoxyphenylacetic acid esters as 15-lipoxygenase inhibitors and SAR comparative studies of them.
Sadeghian H, Attaran N, Jafari Z, Saberi MR, Seyedi SM, Eshghi H, Pordel M, Riazi MM.
Bioorg Med Chem (2009) 17 : 2327 -2335
PubMed 19251422 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.50 5.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL473974 1 5.72
CHEMBL451068 1 5.42
CHEMBL507433 1 4.94
CHEMBL473379 1 4.50
CHEMBL473378 1 4.48
CHEMBL463681 1 4.46
CHEMBL450134 1 4.46
CHEMBL509525 1 4.45
CHEMBL42710 EUGENOL 0.5 1 4.42
CHEMBL449751 1 4.41
CHEMBL473366 1 4.37
CHEMBL502514 1 4.25
CHEMBL445203 1 4.25
CHEMBL464089 1 4.19
CHEMBL470671 ESTRAGOLE 1 4.19
CHEMBL499837 1 4.05
CHEMBL108861 METHYLEUGENOL 1 4.02
CHEMBL473376 1 -
CHEMBL451352 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL473974 IC50 = 1900.0 nM 5.72
CHEMBL451068 IC50 = 3800.0 nM 5.42
CHEMBL507433 IC50 = 11600.0 nM 4.94
CHEMBL473379 IC50 = 32000.0 nM 4.50
CHEMBL473378 IC50 = 33000.0 nM 4.48
CHEMBL463681 IC50 = 35000.0 nM 4.46
CHEMBL450134 IC50 = 34400.0 nM 4.46
CHEMBL509525 IC50 = 35700.0 nM 4.45
CHEMBL42710 EUGENOL IC50 = 38200.0 nM 4.42
CHEMBL449751 IC50 = 38700.0 nM 4.41
CHEMBL473366 IC50 = 43000.0 nM 4.37
CHEMBL502514 IC50 = 56500.0 nM 4.25
CHEMBL445203 IC50 = 56200.0 nM 4.25
CHEMBL464089 IC50 = 64000.0 nM 4.19
CHEMBL470671 ESTRAGOLE IC50 = 64100.0 nM 4.19
CHEMBL499837 IC50 = 88100.0 nM 4.05
CHEMBL108861 METHYLEUGENOL IC50 = 96100.0 nM 4.02
CHEMBL473376 IC50 = 145000.0 nM -
CHEMBL451352 IC50 = 137000.0 nM -