Assay Detail
Binding
CHEMBL1019465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.66 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489324 | — | — | 1 | 5.68 |
| CHEMBL491679 | — | — | 1 | 5.64 |
| CHEMBL491320 | — | — | 1 | - |
| CHEMBL491319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489324 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL491679 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL491320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL491319 | — | IC50 | > | 10000.0 | nM | - |