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Assay Detail

CHEMBL1019600

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Binding
Inhibition of rabbit carboxylesterase after 5 mins
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.
Harada T, Nakagawa Y, Wadkins RM, Potter PM, Wheelock CE.
Bioorg Med Chem (2009) 17 : 149 -164
PubMed 19062296 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.01 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL86668 1 6.85
CHEMBL467450 1 6.82
CHEMBL89506 1 6.82
CHEMBL270375 1 6.80
CHEMBL270374 1 6.80
CHEMBL467451 1 6.66
CHEMBL440542 1 6.60
CHEMBL460809 1 6.39
CHEMBL402615 1 6.38
CHEMBL463556 1 5.96
CHEMBL464002 1 5.60
CHEMBL449475 1 5.57
CHEMBL460807 1 5.32
CHEMBL460806 1 5.31
CHEMBL510996 1 4.87
CHEMBL449775 1 4.82
CHEMBL460808 1 4.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL86668 Ki = 141.25 nM 6.85
CHEMBL467450 Ki = 151.36 nM 6.82
CHEMBL89506 Ki = 151.36 nM 6.82
CHEMBL270375 Ki = 158.49 nM 6.80
CHEMBL270374 Ki = 158.49 nM 6.80
CHEMBL467451 Ki = 218.78 nM 6.66
CHEMBL440542 Ki = 251.19 nM 6.60
CHEMBL460809 Ki = 407.38 nM 6.39
CHEMBL402615 Ki = 416.87 nM 6.38
CHEMBL463556 Ki = 1096.48 nM 5.96
CHEMBL464002 Ki = 2511.89 nM 5.60
CHEMBL449475 Ki = 2691.53 nM 5.57
CHEMBL460807 Ki = 4786.3 nM 5.32
CHEMBL460806 Ki = 4897.79 nM 5.31
CHEMBL510996 Ki = 13489.63 nM 4.87
CHEMBL449775 Ki = 15135.61 nM 4.82
CHEMBL460808 Ki = 22908.68 nM 4.64