Assay Detail
Functional
CHEMBL1019659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha production in human PBMC after 24 hrs by ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 10.34 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475397 | — | — | 1 | 10.92 |
| CHEMBL516398 | — | — | 1 | 10.85 |
| CHEMBL514182 | — | — | 1 | 10.80 |
| CHEMBL492522 | — | — | 1 | 10.60 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.54 |
| CHEMBL494942 | — | — | 1 | 10.51 |
| CHEMBL523499 | — | — | 1 | 10.47 |
| CHEMBL522367 | — | — | 1 | 10.40 |
| CHEMBL474221 | — | — | 1 | 10.35 |
| CHEMBL494941 | — | — | 1 | 10.19 |
| CHEMBL475047 | — | — | 1 | 9.25 |
| CHEMBL474222 | — | — | 1 | 9.23 |
| CHEMBL494338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475397 | — | IC50 | = | 0.012 | nM | 10.92 |
| CHEMBL516398 | — | IC50 | = | 0.014 | nM | 10.85 |
| CHEMBL514182 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL492522 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 0.029 | nM | 10.54 |
| CHEMBL494942 | — | IC50 | = | 0.031 | nM | 10.51 |
| CHEMBL523499 | — | IC50 | = | 0.034 | nM | 10.47 |
| CHEMBL522367 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL474221 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL494941 | — | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL475047 | — | IC50 | = | 0.562 | nM | 9.25 |
| CHEMBL474222 | — | IC50 | = | 0.585 | nM | 9.23 |
| CHEMBL494338 | — | IC50 | < | 1e-08 | nM | - |