Assay Detail
Functional
CHEMBL1019660
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Inhibition of IFN-gamma production in human PBMC after 5 days by ELISA-based mixed lymphocyte reaction assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.98 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492749 | — | — | 1 | 10.60 |
| CHEMBL474221 | — | — | 1 | 9.00 |
| CHEMBL494942 | — | — | 1 | 8.22 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.10 |
| CHEMBL523499 | — | — | 1 | - |
| CHEMBL492522 | — | — | 1 | - |
| CHEMBL514182 | — | — | 1 | - |
| CHEMBL475047 | — | — | 1 | - |
| CHEMBL516398 | — | — | 1 | - |
| CHEMBL474222 | — | — | 1 | - |
| CHEMBL475397 | — | — | 1 | - |
| CHEMBL522367 | — | — | 1 | - |
| CHEMBL494941 | — | — | 1 | - |
| CHEMBL494338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492749 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL474221 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL494942 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL846 | CALCITRIOL | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL523499 | — | IC50 | = | 0.001 | nM | - |
| CHEMBL492522 | — | IC50 | = | 0.001 | nM | - |
| CHEMBL514182 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL475047 | — | IC50 | - | — | - | |
| CHEMBL516398 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL474222 | — | IC50 | - | — | - | |
| CHEMBL475397 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL522367 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL494941 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL494338 | — | IC50 | = | 0.0002 | nM | - |