Assay Detail
Binding
CHEMBL1019786
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Inhibition of CDK9
12
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.19 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526092 | — | — | 2 | 7.77 |
| CHEMBL524266 | — | — | 1 | 7.55 |
| CHEMBL402272 | — | — | 1 | 7.54 |
| CHEMBL445340 | — | — | 2 | 7.51 |
| CHEMBL225519 | — | — | 1 | 7.47 |
| CHEMBL497995 | — | — | 2 | 7.08 |
| CHEMBL451570 | — | — | 1 | 7.02 |
| CHEMBL498200 | — | — | 2 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526092 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL524266 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL402272 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL445340 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL225519 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL526092 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL445340 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL497995 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL451570 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL497995 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL498200 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL498200 | — | IC50 | = | 395.0 | nM | 6.40 |