Assay Detail
Binding
CHEMBL1019895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST fused Bcl-xL binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bcl2-associated agonist of cell death (CHEMBL3817) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.45 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502066 | — | — | 1 | 6.40 |
| CHEMBL508392 | — | — | 1 | 6.09 |
| CHEMBL449546 | — | — | 1 | 5.62 |
| CHEMBL504480 | — | — | 1 | 5.62 |
| CHEMBL451856 | — | — | 1 | 5.52 |
| CHEMBL509208 | — | — | 1 | 5.49 |
| CHEMBL481581 | — | — | 1 | 5.30 |
| CHEMBL473446 | — | — | 1 | 5.25 |
| CHEMBL518649 | — | — | 1 | 5.21 |
| CHEMBL467229 | — | — | 1 | 5.16 |
| CHEMBL481775 | — | — | 1 | 5.10 |
| CHEMBL513318 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502066 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL508392 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL449546 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL504480 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL451856 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL509208 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL481581 | — | IC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL473446 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL518649 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL467229 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL481775 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL513318 | — | IC50 | = | 25200.0 | nM | 4.60 |