Assay Detail
Functional
CHEMBL1020205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse P388/S cells after 72 hrs by colorimetric tetrazolium-formazan method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388/S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.82 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509544 | — | — | 1 | 9.55 |
| CHEMBL502679 | — | — | 1 | 9.48 |
| CHEMBL478720 | — | — | 1 | 9.40 |
| CHEMBL446276 | — | — | 1 | 9.34 |
| CHEMBL455328 | — | — | 1 | 9.32 |
| CHEMBL510006 | — | — | 1 | 9.32 |
| CHEMBL507006 | — | — | 1 | 9.31 |
| CHEMBL448760 | — | — | 1 | 9.31 |
| CHEMBL474561 | — | — | 1 | 9.30 |
| CHEMBL117315 | — | — | 1 | 9.26 |
| CHEMBL475683 | — | — | 1 | 9.23 |
| CHEMBL506902 | — | — | 1 | 9.22 |
| CHEMBL503252 | — | — | 1 | 9.11 |
| CHEMBL505815 | — | — | 1 | 9.05 |
| CHEMBL508108 | — | — | 1 | 9.01 |
| CHEMBL507686 | — | — | 1 | 8.96 |
| CHEMBL507295 | — | — | 1 | 8.96 |
| CHEMBL449831 | — | — | 1 | 8.92 |
| CHEMBL500059 | — | — | 1 | 8.89 |
| CHEMBL503051 | — | — | 1 | 8.89 |
| CHEMBL499795 | — | — | 1 | 8.82 |
| CHEMBL454734 | — | — | 1 | 8.74 |
| CHEMBL452445 | — | — | 1 | 8.74 |
| CHEMBL447826 | — | — | 1 | 8.32 |
| CHEMBL435191 | EDOTECARIN | 3.0 | 1 | 8.32 |
| CHEMBL450991 | — | — | 1 | 8.24 |
| CHEMBL463738 | — | — | 1 | 7.85 |
| CHEMBL455326 | — | — | 1 | 7.68 |
| CHEMBL499103 | — | — | 1 | 7.24 |
| CHEMBL447330 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509544 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL502679 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL478720 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL446276 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL455328 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL510006 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL507006 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL448760 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL474561 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL117315 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL475683 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL506902 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL503252 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL505815 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL508108 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL507686 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL507295 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL449831 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL500059 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL503051 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL499795 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL454734 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL452445 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL447826 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL435191 | EDOTECARIN | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL450991 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL463738 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL455326 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL499103 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL447330 | — | IC50 | = | 190.0 | nM | 6.72 |