Assay Detail
Binding
CHEMBL1020209
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Inhibition of PKC
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.15 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455328 | — | — | 1 | 5.66 |
| CHEMBL509544 | — | — | 1 | 5.17 |
| CHEMBL474561 | — | — | 1 | 5.02 |
| CHEMBL435191 | EDOTECARIN | 3.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455328 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL509544 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL474561 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL435191 | EDOTECARIN | IC50 | = | 18000.0 | nM | 4.75 |