Assay Detail
Functional
CHEMBL1020288
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Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.60 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463913 | — | — | 1 | 7.77 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.92 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.64 |
| CHEMBL518720 | BISCRYPTOLEPINE | — | 1 | 6.57 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.11 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.58 |
| CHEMBL463942 | CRYPTOQUINDOLINE | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463913 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL518720 | BISCRYPTOLEPINE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL463942 | CRYPTOQUINDOLINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 0.17 | ug.mL-1 | - |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 0.042 | ug.mL-1 | - |