Assay Detail
Functional
CHEMBL1020685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human 1A9 cells after 4 days by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Total synthesis and biological evaluation of tubulysin U, tubulysin V, and their analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.08 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 9.70 |
| CHEMBL449058 | TUBULYSIN U | — | 1 | 9.19 |
| CHEMBL449199 | TUBULYSIN V | — | 1 | 6.92 |
| CHEMBL509121 | — | — | 1 | 6.52 |
| CHEMBL454741 | — | — | 1 | 5.29 |
| CHEMBL445270 | — | — | 1 | 4.85 |
| CHEMBL450169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL449058 | TUBULYSIN U | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL449199 | TUBULYSIN V | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL509121 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL454741 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL445270 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL450169 | — | IC50 | > | 50000.0 | nM | - |