Assay Detail
Functional
CHEMBL1020786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B300-19 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.88 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521737 | — | — | 1 | 7.72 |
| CHEMBL508207 | — | — | 1 | 7.41 |
| CHEMBL496356 | — | — | 1 | 7.24 |
| CHEMBL487635 | — | — | 1 | 6.89 |
| CHEMBL486840 | — | — | 1 | 6.89 |
| CHEMBL495736 | — | — | 1 | 6.85 |
| CHEMBL526474 | — | — | 1 | 6.64 |
| CHEMBL495737 | — | — | 1 | 6.41 |
| CHEMBL496152 | — | — | 1 | 6.38 |
| CHEMBL496151 | — | — | 1 | 6.37 |
| CHEMBL496791 | — | — | 1 | - |
| CHEMBL522233 | — | — | 1 | - |
| CHEMBL526495 | — | — | 1 | - |
| CHEMBL499852 | — | — | 1 | - |
| CHEMBL495948 | — | — | 1 | - |
| CHEMBL496147 | — | — | 1 | - |
| CHEMBL463522 | — | — | 1 | - |
| CHEMBL463722 | — | — | 1 | - |
| CHEMBL518386 | — | — | 1 | - |
| CHEMBL499592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521737 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL508207 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL496356 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL487635 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL486840 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL495736 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL526474 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL495737 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL496152 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL496151 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL496791 | — | IC50 | - | — | - | |
| CHEMBL522233 | — | IC50 | - | — | - | |
| CHEMBL526495 | — | IC50 | - | — | - | |
| CHEMBL499852 | — | IC50 | - | — | - | |
| CHEMBL495948 | — | IC50 | - | — | - | |
| CHEMBL496147 | — | IC50 | - | — | - | |
| CHEMBL463522 | — | IC50 | - | — | - | |
| CHEMBL463722 | — | IC50 | - | — | - | |
| CHEMBL518386 | — | IC50 | - | — | - | |
| CHEMBL499592 | — | IC50 | - | — | - |