Assay Detail
Functional
CHEMBL1021536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.24 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38874 | DAMGO | — | 1 | 8.57 |
| CHEMBL509792 | — | — | 1 | 6.92 |
| CHEMBL452991 | — | — | 1 | 6.24 |
| CHEMBL509524 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38874 | DAMGO | EC50 | = | 2.66 | nM | 8.57 |
| CHEMBL509792 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL452991 | — | EC50 | = | 572.0 | nM | 6.24 |
| CHEMBL509524 | — | EC50 | < | 10000.0 | nM | - |