Assay Detail
Binding
CHEMBL1021614
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Binding affinity to HAT p300 catalytic domain by isothermal titration calorimetry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Mechanism of p300 specific histone acetyltransferase inhibition by small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.15 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458934 | CAMBOGIN | — | 1 | 5.23 |
| CHEMBL502489 | GARCINOL | — | 1 | 5.18 |
| CHEMBL500215 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458934 | CAMBOGIN | Kd | = | 5900.0 | nM | 5.23 |
| CHEMBL502489 | GARCINOL | Kd | = | 6600.0 | nM | 5.18 |
| CHEMBL500215 | — | Kd | = | 9100.0 | nM | 5.04 |