Assay Detail
Functional
CHEMBL1021922
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Inhibition of centrosomal clustering in human SCC114 cells expressing GFPalpha-tubulin assessed as mitotic cells with multipolar spindles by fluorescence microscopy
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SCC114 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.45 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL491114 | — | — | 1 | 6.05 |
| CHEMBL522298 | — | — | 1 | 6.05 |
| CHEMBL521969 | — | — | 1 | 6.05 |
| CHEMBL490921 | — | — | 1 | 5.89 |
| CHEMBL491938 | — | — | 1 | 5.89 |
| CHEMBL523820 | — | — | 1 | 5.82 |
| CHEMBL491757 | — | — | 1 | 5.75 |
| CHEMBL490548 | — | — | 1 | 5.70 |
| CHEMBL523777 | — | — | 1 | 5.60 |
| CHEMBL490739 | — | — | 1 | 5.55 |
| CHEMBL491120 | — | — | 1 | 5.54 |
| CHEMBL523471 | — | — | 1 | 5.43 |
| CHEMBL523968 | — | — | 1 | 5.40 |
| CHEMBL489536 | — | — | 1 | 5.18 |
| CHEMBL522763 | — | — | 1 | 5.18 |
| CHEMBL489537 | — | — | 1 | 5.17 |
| CHEMBL492106 | — | — | 1 | 4.82 |
| CHEMBL490124 | — | — | 1 | 4.77 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 4.62 |
| CHEMBL491303 | — | — | 1 | 4.57 |
| CHEMBL492110 | — | — | 1 | - |
| CHEMBL522127 | ISOGRISEOFULVIN | — | 1 | - |
| CHEMBL1612 | — | — | 1 | - |
| CHEMBL489517 | — | — | 1 | - |
| CHEMBL522427 | — | — | 1 | - |
| CHEMBL490556 | — | — | 1 | - |
| CHEMBL522784 | — | — | 1 | - |
| CHEMBL508441 | — | — | 1 | - |
| CHEMBL491954 | — | — | 1 | - |
| CHEMBL491968 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL491114 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL521969 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL522298 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL490921 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL491938 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL523820 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL491757 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL490548 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL523777 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL490739 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL491120 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL523471 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL523968 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL489536 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL522763 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL489537 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL492106 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL490124 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL491303 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL492110 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL522127 | ISOGRISEOFULVIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL1612 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL489517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL522427 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490556 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL522784 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL508441 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL491954 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL491968 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL491304 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490547 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL522614 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490710 | — | IC50 | > | 100000.0 | nM | - |