Assay Detail
Binding
CHEMBL1021956
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Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.58 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 6.70 |
| CHEMBL523822 | — | — | 1 | 6.56 |
| CHEMBL513042 | — | — | 1 | 5.45 |
| CHEMBL470707 | — | — | 1 | 5.45 |
| CHEMBL521636 | — | — | 1 | 5.43 |
| CHEMBL521771 | — | — | 1 | 5.43 |
| CHEMBL471915 | — | — | 1 | 5.40 |
| CHEMBL492175 | — | — | 1 | 5.34 |
| CHEMBL491348 | — | — | 1 | 5.33 |
| CHEMBL523140 | — | — | 1 | 4.72 |
| CHEMBL491513 | — | — | 1 | - |
| CHEMBL489728 | — | — | 1 | - |
| CHEMBL489727 | — | — | 1 | - |
| CHEMBL492089 | — | — | 1 | - |
| CHEMBL489535 | — | — | 1 | - |
| CHEMBL491899 | — | — | 1 | - |
| CHEMBL492180 | — | — | 1 | - |
| CHEMBL491898 | — | — | 1 | - |
| CHEMBL489530 | — | — | 1 | - |
| CHEMBL491964 | — | — | 1 | - |
| CHEMBL471916 | — | — | 1 | - |
| CHEMBL512192 | — | — | 1 | - |
| CHEMBL490503 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL523822 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL513042 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL470707 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL521636 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL521771 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL471915 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL492175 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL491348 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL523140 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL491513 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL489728 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL489727 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL492089 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL489535 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL491899 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL492180 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL491898 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL489530 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL491964 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL471916 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL512192 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL490503 | — | IC50 | > | 30000.0 | nM | - |