Assay Detail
Binding
CHEMBL1021975
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Inhibition of cathepsin B by spectrofluorimetry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.71 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | — | 1 | 7.33 |
| CHEMBL452483 | GUTTIFERONE A | — | 1 | 5.68 |
| CHEMBL470519 | EPICLUSIANONE | — | 1 | 4.13 |
| CHEMBL470520 | GARCINIAPHENONE | — | 1 | - |
| CHEMBL470701 | — | — | 1 | - |
| CHEMBL90039 | BENZOPHENONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL452483 | GUTTIFERONE A | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL470519 | EPICLUSIANONE | IC50 | = | 73700.0 | nM | 4.13 |
| CHEMBL470520 | GARCINIAPHENONE | IC50 | = | 103500.0 | nM | - |
| CHEMBL470701 | — | IC50 | = | 198000.0 | nM | - |
| CHEMBL90039 | BENZOPHENONE | IC50 | = | 288800.0 | nM | - |