Assay Detail
Binding
CHEMBL1022015
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Inhibition of human recombinant DPP8
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.45 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474410 | — | — | 1 | 6.28 |
| CHEMBL474409 | — | — | 1 | 6.27 |
| CHEMBL475573 | — | — | 1 | 6.01 |
| CHEMBL475574 | — | — | 1 | 5.94 |
| CHEMBL475246 | — | — | 1 | 5.65 |
| CHEMBL475586 | — | — | 1 | 5.62 |
| CHEMBL515597 | — | — | 1 | 5.58 |
| CHEMBL515387 | GOSOGLIPTIN | 4.0 | 1 | 5.16 |
| CHEMBL515869 | — | — | 1 | 5.10 |
| CHEMBL514011 | — | — | 1 | 5.04 |
| CHEMBL473418 | — | — | 1 | 5.01 |
| CHEMBL473419 | — | — | 1 | 4.99 |
| CHEMBL514623 | — | — | 1 | 4.82 |
| CHEMBL474421 | — | — | 1 | 4.77 |
| CHEMBL472992 | — | — | 1 | - |
| CHEMBL472993 | — | — | 1 | - |
| CHEMBL473188 | — | — | 1 | - |
| CHEMBL472995 | — | — | 1 | - |
| CHEMBL514935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474410 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL474409 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL475573 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL475574 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL475246 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL475586 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL515597 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL515387 | GOSOGLIPTIN | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL515869 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL514011 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL473418 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL473419 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL514623 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL474421 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL472992 | — | IC50 | - | — | - | |
| CHEMBL472993 | — | IC50 | - | — | - | |
| CHEMBL473188 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL472995 | — | IC50 | - | — | - | |
| CHEMBL514935 | — | IC50 | - | — | - |