Assay Detail
Binding
CHEMBL1022016
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Inhibition of human recombinant DPP4
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.64 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514011 | — | — | 1 | 8.32 |
| CHEMBL474410 | — | — | 1 | 8.28 |
| CHEMBL475586 | — | — | 1 | 8.28 |
| CHEMBL474409 | — | — | 1 | 8.25 |
| CHEMBL475574 | — | — | 1 | 8.24 |
| CHEMBL475573 | — | — | 1 | 8.13 |
| CHEMBL515597 | — | — | 1 | 8.09 |
| CHEMBL475246 | — | — | 1 | 8.06 |
| CHEMBL474421 | — | — | 1 | 7.89 |
| CHEMBL515387 | GOSOGLIPTIN | 4.0 | 1 | 7.89 |
| CHEMBL515869 | — | — | 1 | 7.60 |
| CHEMBL473418 | — | — | 1 | 7.51 |
| CHEMBL514623 | — | — | 1 | 7.51 |
| CHEMBL473188 | — | — | 1 | 7.39 |
| CHEMBL473419 | — | — | 1 | 7.29 |
| CHEMBL514935 | — | — | 1 | 6.87 |
| CHEMBL472993 | — | — | 1 | 6.51 |
| CHEMBL472992 | — | — | 1 | 6.51 |
| CHEMBL472995 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514011 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL474410 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL475586 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL474409 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL475574 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL475573 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL515597 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL475246 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL474421 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL515387 | GOSOGLIPTIN | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL515869 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL473418 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL514623 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL473188 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL473419 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL514935 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL472993 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL472992 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL472995 | — | IC50 | = | 338.0 | nM | 6.47 |