Assay Detail
Binding
CHEMBL1022131
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Inhibition of rat recombinant protein farnesyltransferase expressed in Sf9 cells by [3H]-scintillation proximity assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rational modification of a candidate cancer drug for use against Chagas disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.51 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 9.15 |
| CHEMBL514400 | — | — | 1 | 8.40 |
| CHEMBL471607 | — | — | 1 | 7.89 |
| CHEMBL510213 | — | — | 1 | 7.77 |
| CHEMBL456001 | — | — | 1 | 6.53 |
| CHEMBL456002 | — | — | 1 | 6.52 |
| CHEMBL470996 | — | — | 1 | 6.31 |
| CHEMBL471195 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL514400 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL471607 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL510213 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL456001 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL456002 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL470996 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL471195 | — | IC50 | > | 5000.0 | nM | - |